中药材2011，Vol.34Issue(11)：1746-1749,4.
木樨草素对脂多糖诱导的小胶质细胞炎性反应的抑制作用
The Inhibitory Effect of Luteolin on Inflammation in LPS-induced Microglia
摘要
Abstract
Objective;To study the inhibitory effect of Luteolin on LPS-induced BV-2 cell. Methods:BV-2 cells were treated with LPS (0. 1μg/mL) for inflammation model;MTT assay was used to detect the viability of BV-2 cells ;Nitric oxide (NO) was detected by the method of nitric acid reductase assay; Induce type II nitric oxide synthase (iNOS) enzyme activity was determined by type of nitric oxide synthase assay ;TLR4 protein expression was examined by the Western Blot analysis. Results: Luteolin significantly decreased the NO production and TLR4 protein expression as well as iNOS activity in LPS-activated microglial cell. Conclusion; LPS induced activation of microglia lead to inflammatory response and its mechanism may be related to inhibiting TLR4 signaling pathway.关键词
木樨草素/小胶质细胞/脂多糖/神经炎症Key words
Luteolin/ Microglia/Lipopolysaccharides/Neuroinflammation分类
医药卫生引用本文复制引用
黄丰,朱苗苗,邓华明,张在军,杨丽,肖飞,肖瑛,聂红..木樨草素对脂多糖诱导的小胶质细胞炎性反应的抑制作用[J].中药材,2011,34(11):1746-1749,4.基金项目
广东省医学科研基金(A2010344) （A2010344）
暨南大学药学院211工程和重点实验室创新研究项目 （）
国家自然科学基金(81073129) （81073129）
