中药材2011，Vol.34Issue(12)：1912-1915,4.
北五味子提取物小鼠体内药动学和组织分布研究
Pharmacokinetics and Tissue Distribution of Schisandra chinensis Extract in Mice
摘要
Abstract
Objective: To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice. Methods: Schisandrin in mice plasma and tissues including heart,liver,spleen,lung and kidney was quantitatively determined by HPLC. Results: The concentration-time curve of Schisandra chinensis extract was described by a single compartment model,Cmax was (2. 17 ±0. 27)mg/ mL,tmax was (1. 00 ±0. 32) h, AUC0→∞ was (4. 07 ±0. 62) mg·h/mL. The sequence of distribution of schisandrin in mice body was as follows: liver > plasma > kidney > lung > heart > spleen. Conclusion: The distribution of extract in the body is abroad. Liver has relative high concentration of schisandrin,which is beneficial to the treatment of hepatic disease.关键词
北五味子/五味子醇甲/药动学/组织分布/高效液相色谱法Key words
Schisandra chinensis (Turcz.)Baill. /Schisandrin/Pharmacokinetics/Tissue distribution/HPLC分类
医药卫生引用本文复制引用
关皎,朱鹤云,张秀荣,赵阳,孙德一..北五味子提取物小鼠体内药动学和组织分布研究[J].中药材,2011,34(12):1912-1915,4.基金项目
吉林省教育厅"十一五"科学技术研究项目(吉教科合字[ 2008]第263号) （吉教科合字[ 2008]第263号）
