中医药学报2011，Vol.39Issue(6)：21-23,3.
寒、热方剂对束缚水浸应激型胃溃疡寒、热证模型大鼠血清TXB2、NT含量的影响
The Influence of Cold or Heat Prescription on TXB2, NT Contents in Serum on Gastric Ulcer Induced by Bondage Water Immersion Stress Combined with Cold or Heat Syndrome Model Rats
摘要
Abstract
Objective: To explore the forming mechanism of gastric ulcer model induced by bondage water immersion stress combined with cold or heat syndrome. And to observe the basic mechanism of action and objective regularity of " formula - syndrome corresponding" of cold or heat formula on gastric ulcer model combined with cold or heat syndrome. Methods; Adopting cold or heat factors combined with bondage water immersion stress methods to establish gastric ulcer model combined with cold and heat syndrome. Using euzymelinked immunosorbent assay to detect the contents of TXB2 ,NT in serum. Results:Compared with the blank group, the contents of TXB2 in serum increased remarkably in each model groups (P <0. 01). The contents of TXB2 increased more remarkably in "disease - syndrome combination" model than those in simple syndrome or simple disease model. Compared with the blank group, the contents of NT in serum decreased remarkably in each model group(P<0.05 or P <0. 01). But there is no obvious difference among the model groups. Dahuang Huanglian Xiexin decoction or Lizhong pill could respectively decreased the contents of TXB2 and increase the contents of NT in serum of heat - ulcer group or cold - ulcer group obviously ( P < 0.05 or P < 0.01). Conclusions; On the basis of the theory of "formula - syndrome corresponding" , verifying the feasibility of duplicating "disease -syndrome combination" model, that is gastric ulcer model combined with cold or heat syndrome. The therapeutic action of Dahuang Huanglian Xiexin decoction on heat - gastric ulcer, or Lizhong pill on cold - gastric ulcer can both be achieved by decreasing the contents of TXB2, increasing the contents of NT in serum.关键词
束缚水浸应激/胃溃疡/寒、热证/TXB2/NTKey words
Bondage water immersion stress/ Gastric ulcer/Cold or heat syndrome/TXB2/NT分类
医药卫生引用本文复制引用
李冀,柴剑波,李胜志,赵雪莹,毕珺辉,高彦宇..寒、热方剂对束缚水浸应激型胃溃疡寒、热证模型大鼠血清TXB2、NT含量的影响[J].中医药学报,2011,39(6):21-23,3.基金项目
"十一五"国家科技支撑计划项目-"方证相应"模式之复方药理研究(2006 BA108B04-03) （2006 BA108B04-03）
