中医药信息2012，Vol.29Issue(1)：17-20,4.
西洋参干预胰岛素抵抗大鼠活性部位的化学成分研究Ⅴ
The Intervention of Chemical Constituents of Active Site from American Ginseng in Insulin Resistance Rats
摘要
Abstract
Objective: To study the chemical constituents of active site that American ginseng treats rat insulin resistance. Methods:They were extracted by ethanol and adsorbed by macroreticular resins, then eluted with ethanol and isolated by silicagel column chromatography and HPLC preparation chromatography. Their structures were determined by physical and chemical properties as well as spectrographical identification. Result and Conclusion: Three compounds were isolated from the active site that American ginseng treats rat insulin resistance. Their structures were identified as3-O-β-D- glucopyranosyl - (1→2) - β - D - glucopy -ranosyl -20-O-β-D- arabinopyranosyl - (1→-6) - β - D - glucopyranosyl - dammar - 24 - ene - 3β, 12β,20S - triol (Ⅰ) ,3-O-β-D- glucopyranosyl - ( 1→2 ) - β - D - glucopyranosyl - 20 - O - β -D - glucopyranosyl - (1 →-6) - β - D - xylopyranosyl - dammara - 24 - ene -3(3,12β,20S - triol ( Ⅱ ) , dram - mar - 25 (26) - ene - 3 β,12β,20S, 24￡ - ietraol -20-O-β-D- glucopyranosyl - (1 →-2) -β - gl - ucopyranoside ( Ⅲ ).关键词
西洋参/活性部位/胰岛素抵抗/化学成分Key words
American ginseng/Active site/Insulin resistance/Chemical constituents分类
医药卫生引用本文复制引用
李冀,马育轩,葛鹏玲,杨炳友,尚广巍..西洋参干预胰岛素抵抗大鼠活性部位的化学成分研究Ⅴ[J].中医药信息,2012,29(1):17-20,4.基金项目
国家自然科学基金项目(30672632) （30672632）
黑龙江省杰出青年科学基金项目(JC04-01) （JC04-01）
黑龙江省博士后科学基金(LRB09-321) （LRB09-321）
黑龙江省留学回国人员科技项目择优资助基金 （）
