组织工程与重建外科杂志2011，Vol.7Issue(6)：313-316,4.DOI:10.3969/j.issn.1673-0364.2011.06.004
婴幼儿脑积水脑室-腹腔分流术引流管堵塞危险因素及间充质干细胞治疗的影响
The Risk Factors of Ventriculo-peritoneal Shunt Tube Blockage in Infantile Hydrocephalus and the Effect of Mesenchymal Stem Cell Therapy Prior to Surgery
许智蕾 1陆永建 1刘薇薇 2余卫2
作者信息
- 1. 510150 广东省广州市 广州医学院附属第二医院神经外科
- 2. 510620 广东省广州市广州市第十二人民医院
- 折叠
摘要
Abstract
Objective To investigate the risk factors of ventriculo - peritoneal shunt tube blockage after surgery in infant with hydrocephalus and the effect of preoperative administration of umbilical cord mesenchymal stem cells (Mesenchymal stme cells, MSC) on the incidence of this complication. Methods A retrospective analysis was conducted in 125 cases of infant with hydrocephalus to evaluate the occurrence of shunt blockage during the follow-up of 2 years after ventriculo -peritoneal drainage. Further, the incidence and its associated factors in 11 cases who received intravenous infusion of MSC treatment preoperatively were also analyzed. Results The clinical risk factors included preoperative cerebrospinal fluid cell count, cerebrospinal fluid protein content, age, terminal of location drainage tube and serum albumin concentrations orderly. MSC treatment significantly increased serum albumin level and decreased the occurrence of drainage tube obstruction (1/11 vs. 53/114, P<0.01). Conclusion Preoperative infusion of MSC can increase the level of serum albumin and reduce postoperative complications.关键词
脑积水/脑室-腹腔分流术/并发症/间充质干细胞/危险因素Key words
Hydrocephalus/Ventriculo-peritoneal drainage/Complication/Mesenchymal stem cells/Risk factor分类
医药卫生引用本文复制引用
许智蕾,陆永建,刘薇薇,余卫..婴幼儿脑积水脑室-腹腔分流术引流管堵塞危险因素及间充质干细胞治疗的影响[J].组织工程与重建外科杂志,2011,7(6):313-316,4.
