北京生物医学工程2012，Vol.31Issue(2)：200-207,8.DOI:10.3969/j.issn.1002-3208.2012.02.19.
基于ABM探讨吸烟对重度哮喘影响的机制
Effect mechanism of severe asthma caused by smoking based on ABM
宋丽艳 1郭云波 2邓亲恺 2李金明2
作者信息
- 1. 广州医学院基础学院,广州,510182
- 2. 南方医科大学基础医学院,广州,510515
- 折叠
摘要
Abstract
Objective To explore the mechanism of severe asthma caused by smoking and establish the theoretical basis for the therapy of severe asthma with smoking. Methods We take the basic immune simulator (BIS) as a platform to simulate TH17 models for immune system influence, compare with the DCs models made in BIS, and combine smoking clinical data to verify the models' correctness. Results The mechanism of severe asthma caused by smoking may be that the oxidants in smoking can stimulate mature DCs to produce IL-8, the longer acting time with smoking, the more IL - 8 agents are produced and asthma becomes more severe. Conclusions DCs- IL-23-TH17- IL8-neutrophile inflammation may be the path of severe asthma. TH17 as a target, DCs reduced and pathway of IL23-TH17-IL8 cut off, symptom with severe asthma caused by smoking may be controlled.关键词
吸烟/重度哮喘/机制/路径Key words
smoking/ severe asthma/ mechanism/ path分类
医药卫生引用本文复制引用
宋丽艳,郭云波,邓亲恺,李金明..基于ABM探讨吸烟对重度哮喘影响的机制[J].北京生物医学工程,2012,31(2):200-207,8.
