重庆医学2012，Vol.41Issue(10)：948-950,3.DOI:10.3969/j.issn.1671-8348.2012.10.005
白细胞介素-27的基因多态性与大肠癌的遗传易感性之间的相关性研究
Association of interleukin-27 gene polymorphism with genetic susceptibility to colorectal cancer
摘要
Abstract
Objective To investigate the single nucleotide polymorphisms (SNPs) and its haplotypes of interleukin-27 (IL-27) gene are associated with susceptibility to colorectal cancer (CRC) in a Chinese population. Methods We analyzed two single nucleotide polymorphisms of IL-27 gene promoter -964 A/G and 2905 T/G in 170 patients with CRC and 160 age and sex matched controls in a Chinese population, using a polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) strategy, Frequency of haplotypes and linkage disequilibrium of IL-27 gene in different groups were analyzed by SHKsis programs. Results The distributions of IL-27 gene 2905 T/G polymorphism was not different between CRC and control group,but the IL-27 gene -964 A/G polymorphism was significantly different(P<0. 05). The relative risk suffered from CRC of G allele was I. 640 times of the A allele carriers (OR= 1.640,95%CI:l. 194~2. 251). Consistent with the results of the genotyping analyses,IL-27 -964 A/G and 2905 T/G polymorphisms showed strong linkage disequilibrium( |D' | = 0. 937) ,frequency of the -964 G /2905 G haplotype in patients with CRC was significant higher than that in controls(P<0. 05). The -964 G /2905 G haplotype was associated with a significantly increased risk of CRC (OR = 2. 100,95%CI:1. 176 ~ 3. 749). Conclusion IL-27 gene -964 A/G polymorphism and its -964 G /2905 G haplotype are associate with CRC, - 964 G allele is an important genetic susceptibility gene for CRC.关键词
白细胞介素-27/大肠癌/多态性,单核苷酸/单倍型Key words
interleukin-27/colorectal cancer/polymorphism,single nucleotide/haplotype引用本文复制引用
郭俊宇,覃安强,李如锟,杨昌谋,黄甫达,黄展易,郭厚基..白细胞介素-27的基因多态性与大肠癌的遗传易感性之间的相关性研究[J].重庆医学,2012,41(10):948-950,3.基金项目
广西教育厅基金资助项目(200810LX085). （200810LX085）
