重庆医学2012，Vol.41Issue(10)：959-960,963,3.DOI:10.3969/j.issn.1671-8348.2012.10.009
右美托咪啶对异丙酚靶控输注时瑞芬太尼抑制气管插管反应的半数有效血浆浓度的影响
Effect of dexmedetomidine on efective target plasma concentrations of remifentanil required to prevent tracheal intubation response in 50% of patients anesthetized with propofol by TCI
赵晓虹 1高成杰 1王建 1王惠霞 1刘健1
作者信息
- 1. 济南军区总医院麻醉科,济南,250031
- 折叠
摘要
Abstract
Objective To observe the effect of single dose dexmedetomidine on efective target plasma concentrations of remifen-tanil required to prevent tracheal intubation response in 50% of adult patients (Cp50 ) anesthetized with propofol by TCI. Methods Forty ASA class I or II patients,aged 18 to 60 years old, with body mass index 20 - 30 kg/m2 undergoing elective general anesthesia were enrolled in the study. The patients were randomly divided into 2 groups:dexmedetomidine (D) group and control (C) group. Group D received dexmedetomidine 0. 4 μg/kg by intravenous injection,and the whole dose was given within 5 minutes,and Group C received equal volume of normal saline as Group D intravenously without dexmedetomidine,observed 10 min before induction of anesthesia. Remifentanil was administered by TCI for 5 min followed by propofol given by TCI at a target plasma concentration of 3 mg/L. When the patients lost consciousness, intravenous rocuronium was given to facilitate tracheal intubation. The ratio of two consecutive target plasma concentration was 1. 2. Results The Cp50 of remifentanil in Group D and Group C were 2. 88 μg/L and 3. 72 μg/L,respectively. The 95% confidence intervals were 2. 75-3. 02 μg/L and 3. 54 -3. 89 μg/L,respectively. Conclusion The Cp50 values of remifentanil for suppression of tracheal intubation response were 2. 88μg/L and 3. 72 μg/L in Group D and Group C respectively. Dexmedetomidine reduce the Cp50 values of remifentanil for suppression of tracheal intubation response. It may involve in the synergetic effect between dexmedetomidine and remifentanil.关键词
右美托咪啶/瑞芬太尼/二异丙酚/剂量效应关系,药物/插管法,气管内Key words
dexmedetomidine/ remifentanil/ propofol/ dose response relationship, drug/ intubation, intratracheal引用本文复制引用
赵晓虹,高成杰,王建,王惠霞,刘健..右美托咪啶对异丙酚靶控输注时瑞芬太尼抑制气管插管反应的半数有效血浆浓度的影响[J].重庆医学,2012,41(10):959-960,963,3.
