摘要
Abstract
Objective To observe the level of plasma omentin-1 in the patients with essential hypertension and its relationship with blood pressure(BP)and insulin resistance(IR). Methods 42 patients with essential hypertension and 38 normotensive healthy subjects were studied. Fasting plasma omentin-1 level was assayed by ELISA technique,and the related parameters such as BP,body mass index(BMI) , waist hip ratio(WHR) , fasting blood glucose(FBG) ,and insulinC Fins) were measured. According to the typical HOMA model, insulin resistance index(HOMA-IR) was calculated. Results The level of plasma omentin-1 in essential hypertension group was significantly lower than that in normotensive healthy subjects(18. 15 + 5. 33) ng/mL vs. (24. 37 + 6. 82) ng/mL, P <0. 01). Plasma omentin-1 in the essential hypertension group was negatively related to systolic blood pressure(SBP) ,BMI,WHR, Fins, HOMA-IR,interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α) (r= -0. 371, -0. 313 , - 0. 364 , - 0. 272 , - 0. 438 , - 0. 296 , - 0. 217,P<0. 05). Multiple regression analysis showed that SBP and HOMA-IR were the independent risk factors of plasma omentin-1 in the patients with essential hypertension. Conclusion The plasma omentin-1 is significant lower in the patients with essential hypertension,and there are significant negative correlations between omentin-1 with SBP and IR.关键词
高血压/胰岛素抗药性/网膜素-1Key words
hypertension/insulin resistance/omentin-1
