重庆医学2012，Vol.41Issue(14)：1358-1360,封2,4.DOI:10.3969/j.issn.1671-8348.2012.14.003
慢性铝负荷致小鼠神经元退行性改变与脑内锰离子关系的研究
Study on relationship between manganese level and neurodegeneration induced by chronic aluminum overload in mice
邱红梅 1何百成 1周岐新1
作者信息
- 1. 重庆医科大学药学院药理教研室,400016
- 折叠
摘要
Abstract
To investigate the possible mechanism of neurodegeneration caused by chronic aluminum overload in mice. Methods 140 healthy male NIH mice were selected and randomly divided into the aluminum overload group and the control group, 70 cases in each group. 45% aluminum gluconate solution(0. 2 mL/10 g) was given by intragastric gavage in the aluminum overload group,once a day, 6 d per week for 12 weeks. The control group was given isovolumetric distilled water. The learning and memory functions, histopathogical changes of hippocampus, as well as the concentrations of manganese in hippocampus and cerebra were compared between the two groups. Results Both functions of passive learning and memory and spatial recognition were significantly decreased from 4 weeks. Hippocampal neurocytes showed pyknosis and lost,as well as the manganese level was significantly increased from 6 weeks in time-dependent manner. Conclusion Chronic aluminum overload can cause neurodegeneration and learning and memory dysfunction in mice obviously, its mechanism may be related with the aluminum-induced metabolic disturbance of in-tracerebral manganese metal ions.关键词
铝/锰/神经元退行性改变/铝负荷Key words
aluminum/manganese/neurodegeneration/aluminum overloading引用本文复制引用
邱红梅,何百成,周岐新..慢性铝负荷致小鼠神经元退行性改变与脑内锰离子关系的研究[J].重庆医学,2012,41(14):1358-1360,封2,4.
