重庆医学2012，Vol.41Issue(14)：1392-1393,1396,封2,封3,5.DOI:10.3969/j.issn.1671-8348.2012.14.018
前胡丙素对自发性高血压大鼠血压及心肌受磷蛋白表达的影响
Effects of praeruptorin C on blood pressure and expression of myocardial phospholamban in spontaneously hypertensive rats*
摘要
Abstract
To explore the impact and the possible mechanism of prearuptorin C(Pra-C) on blood pressure in spontaneously hypertensive rats(SHR). Methods 20 spontaneously hypertensive rats were randomly divided into the Pra-C group treated with Pra-C 20 mg/(kg-1 ? D-1 ) by gastrogavage(n = 10) and untreated control group(n = 10). The untreated control group and 10 age matched Sprague Dawley rats as SD group received gastrogavage with same volume of polyethylene glycol. Kach rat in various groups was intervened for 8 weeks. The lesions of ultrastructure and mitochondria were observed by transmission electron microscope. The gene expression levels of phospholamban(PLB) were determined by the method of semiquantitative RT-PCR. Results Before treatment,the systolic pressure of SHR in the Pra-C group was (184. 3+ 19. 7)mm Hg, which was closed to (183. 3 + 17. 2)mm Hg in the control group,but significantly higher than that in the SD group. After treatment,the systolic pressure of SHR in the Pra-C group was (149. 3 + 12. 6)mm Hg, which was obviously lower than(201. 0+11. 0)mm Hg in the control group(P＜ 0. 05). Compared with the SD group, the expression of PLB in the control group was significantly reduced, but which after treatment in the Pra-C group was upregulated compared with the control group(P＜0. 05). Conclusion Pra-C has a certain hypotensive effect by upregulating the gene expression of myocardial sarcoplasmic reticulum PLB.关键词
大鼠,近交SHR/高血压/前胡丙素/受磷蛋白Key words
rats, inbred SHR/ hypertension/ praeruptorin/ phospholamban引用本文复制引用
汪文杰,孙黎明..前胡丙素对自发性高血压大鼠血压及心肌受磷蛋白表达的影响[J].重庆医学,2012,41(14):1392-1393,1396,封2,封3,5.基金项目
连云港市重点人才课题(Zc229). （Zc229）
