南方医科大学学报2012，Vol.32Issue(1)：106-108,3.DOI:44-1627/R.20120101.1040.003
复方抗肝纤维化处方的优化
Optimization of a compound prescription for treating liver fibrosis
摘要
Abstract
Objective To optimize a compound prescription for treatment of liver fibrosis with an improved therapeutic effect and low toxidty. Methods In rat models of liver fibrosis induced by thioacetamide (TAA), the optimized prescription was screened based on a uniform design with 2-factor 5-level table using Uniform Design 3.0 software and tested using liver content of Hyp as the screening index. To verify the efficacy of the optimized prescription, the rat models of liver fibrosis were randomized into normal control group, model group, colchicine group and optimized prescription group, and the changes of hepatic Hyp content, serum HA, ALT, AST, and ALB levels, and the pathology liver fibrosis were observed after corresponding treatments. Results The optimized prescription, which contained 70 mg/kg glycyrrhizin and 70 mg/kg matrine, showed a significant therapeutic effect against liver fibrosis in rats (P＜0.05), and the effect was equivalent to that of colchicine (P＞0.05). Conclusion Uniform design is a valuable method in prescription optimization. The optimized compound prescription of matrine and glycyrrhizin has a significant effect in inhibiting liver fibrosis.关键词
均匀设计/肝纤维化/甘草甜素/苦参碱Key words
uniform design/ liver fibrosis/ glycyrrhizin/ matrine分类
医药卫生引用本文复制引用
黄亮,漆林艳,陈志良,李亦蕾,文志勇..复方抗肝纤维化处方的优化[J].南方医科大学学报,2012,32(1):106-108,3.基金项目
广东省自然科学基金(S2011010003868) （S2011010003868）
