南方医科大学学报2012，Vol.32Issue(1)：119-121,3.DOI:44-1627/R.20120101.1318.019
二氧化碳气腹对腹腔镜下移植肾功能的影响
Effect of CO2 pneumoperitoneum on renal function in rats
摘要
Abstract
Objective To evaluate the effects of different CO2 pneumoperitoneum conditions on renal function in rats and provide experimental evidence for improving renal graft function after transplantation. Methods SD rats were randomized into 10 groups (n=12) and subject to CO2 pneumoperitoneum at different pressures (0.67, 1.33 and 2.0 kPa) for 60 or 120 min. Serum urea nitrogen (BUN), creatinine (Cr) and N-acetyl-β-D-glocosaminidase (NAG) levels were detected after pneumoperitoneum. Results As the pressure and time of pneumoperitoneum increased, the renal function deteriorated gradually, showing significant differences between the groups (P<0.05). Conclusion Increased pressure and prolonged duration of CO2 pneumoperitoneum causes impairment of the renal function, suggesting the necessity of reducing the operative time and lowering the pressure of pneumoperitoneum when harvesting renal graft in living donors.关键词
二氧化碳气腹/肾功能/大鼠Key words
CO2 pneumoperitoneum/ renal function/ rats分类
医药卫生引用本文复制引用
徐战平,蒲小勇,杨浣情,郑祥光,刘久敏..二氧化碳气腹对腹腔镜下移植肾功能的影响[J].南方医科大学学报,2012,32(1):119-121,3.基金项目
广东省医学科学基金(A2008038) （A2008038）
