南方医科大学学报2012，Vol.32Issue(2)：151-154,4.DOI:44-1627/R.20120209.1526.032
染料木黄酮通过上调血红素氧合酶-1表达减缓野百合碱诱导的大鼠肺动脉高压
Genistein attenuates monocrotaline-induced pulmonary arterial hypertension in rats by up-regulating heme oxygenase-1 expression
摘要
Abstract
Objective To study the effect of genistein on the expression of heme oxygenase-1 (HO-1) in rats with pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). Methods Sixty male Sprague-Dawley rats were randomly divided into 4 groups (n=15), namely the control group, model group, low-dose (20 μg/kg) genistein group and high-dose (80 μg/kg) genistein group. The hemodynamic parameters were measured and the remodeling of pulmonary small arteries was observed by electron microscope (EM). The expression of HO-1 in the lung tissues were detected by Western blotting. Results Compared with the model group, genistein treatment significantly reduced the elevated mean pulmonary arterial pressure, improved the right ventricular hypertrophy index, and increased the expression of HO-1 in a dose-dependent manner. Conclusion Genistein attentuates pulmonry arterial hypertension in MCT-treated rats possibly by up-regulation of HO-1 in the lung tissues.关键词
肺动脉高压/野百合碱/染料木黄酮/血红素氧和酶-1Key words
pulmonary arterial hypertension/ monocrotaline/ genistein/ heme oxygenase-1分类
医药卫生引用本文复制引用
张玉坤,王导新,朱涛,李长毅..染料木黄酮通过上调血红素氧合酶-1表达减缓野百合碱诱导的大鼠肺动脉高压[J].南方医科大学学报,2012,32(2):151-154,4.基金项目
国家自然科学基金(30971303) （30971303）
