南方医科大学学报2012，Vol.32Issue(2)：215-217,3.DOI:44-1627/R.20120209.1344.010
热应激对大鼠肝脏节律性基因Per2mRNA表达水平的影响
Effects of heat stress on Per2 mRNA expression in the liver of rats
摘要
Abstract
Objective To investigate the effect of acute heat stress on the day-night arcadian gene Perl mRNA expression in the liver of rats. Method Male Wistar rats were randomly divided into two groups and exposed to heat at 32 ℃ or to a room temperature at 24 ℃ (control). After 7 days of heat exposure, the body temperature was measured by telemetry. The relative weight of the pituitary and adrenal glands was determined after the exposure, and liver Perl mRNA expression level was detected using RT-PCR. Results Acute heat stress did not obviously affect body temperature or body weight of the rats. Seven days of heat exposure increased the relative weight of the pituitary and adrenal glands and significantly lowered Perl mRNA expression level at night. Conclusion Acute heat stress can interfere with the day-night circadian gene Perl mRNA expression in rats.关键词
热应激/脑垂体/肾上腺/肝脏/Per2Key words
heat stress/ pituitary/ adrenal gland/ liver/ Perl分类
医药卫生引用本文复制引用
李光华,李红,张庆华,刘红梅,刘宏鹏,紫藤治..热应激对大鼠肝脏节律性基因Per2mRNA表达水平的影响[J].南方医科大学学报,2012,32(2):215-217,3.基金项目
国家自然科学基金(81060230) （81060230）
宁夏自然科学基金(NZ10111) （NZ10111）
