南方医科大学学报2012，Vol.32Issue(3)：322-328,7.DOI:44-1627/R.20120308.0919.005
阿托伐他汀对老年大鼠心肌缺血再灌注损伤及多器官功能的保护作用
Protective effect of atrovastatin against myocardial ischemia-reperfusion injury and on liver and kidney functions in aged rats
摘要
Abstract
Objuctive To observe the effect of atorvastatin against myocardial ischemia-reperfusion injury and its protective effect on liver and kidney functions. Methods Ten-month-old Wistar rats were fed to the age of 20 months, and atorvastatin statins gavage was administered till 24 months. The rats were divided into high-dose statin group, small-dose statin group, aged control group and young control group. The myocardial ischemia-reperfusion model was established by ligating the coronary artery. The mortality, hemodynamic changes, infarct size and liver and kidney functions of the rats were recorded or measured. Results Compared with the aged control group, the young control group and high-dose statin group showed significantly lower mortality rate, reduced hemodynamic abnormalities, and smaller myocardial infarct size following myocardial ischemia-reperfusion (P<0.05). The liver and kidney functions of the young control group and high-dose statin group underwent no significant deterioration after myocardial ischemia and reperfusion, but those in the small-dose statin group and aged control group showed significant deteriorations (P<0.05). Conclusion Atorvastatin offers protective effects on the heart, liver, and kidney in the event of myocardial ischemia-reperfusion in aged rats.关键词
老年/阿托伐他汀/缺血再灌注/肝肾功能Key words
aging/ atorvastatin/ ischemia-reperfusion/ liver and kidney functions分类
医药卫生引用本文复制引用
张今尧,王浩,叶平..阿托伐他汀对老年大鼠心肌缺血再灌注损伤及多器官功能的保护作用[J].南方医科大学学报,2012,32(3):322-328,7.基金项目
国家自然科学基金(30972713) （30972713）
