南方医科大学学报2012，Vol.32Issue(3)：420-422,3.DOI:44-1627/R.20120307.1723.027
结直肠癌中NOB1基因的表达及意义
Expression of NOB1 and its significance in colorectal cancer
摘要
Abstract
Objective To investigate the expression of NOB1 in colorectal cancer and its relationship with the clinicopathological characteristics. Methods The expression of NOB1 was detected immunohistochemically in 60 primary colorectal cancer tissues and the corresponding normal epithelia (3.0 cm away from the cancer margin) and graded according to the staining intensity and the percentage of positively stained tumor cells. Results NOB1 overexpression was found in 32 of the 60 cases (53.3%). NOB1 overexpression in the adjacent non-neoplastic tissues was found in 10 of the cases (16.7%), a rate significantly lower than that in the cancer tissues (P<0.05). NOB1 expression was not correlated to such tumor characteristics as gender, age, histological differentiation grade, depth of invasion and lymph node metastasis (P>0.05). Conclusions NOB1 expression is higher in colorectal cancer than in normal colorectal tissues, suggesting its involvement in the tumorigenesis and progression of colorectal cancer.关键词
NOBl/结直肠癌/免疫组化染色Key words
NOB1/ colorectal cancer/ immunohistochemistry分类
医药卫生引用本文复制引用
吴东平,贺孝文..结直肠癌中NOB1基因的表达及意义[J].南方医科大学学报,2012,32(3):420-422,3.基金项目
浙江省医药卫生科技计划A类项目(2010KY178) （2010KY178）
