癌症（英文版）2012，Vol.31Issue(3)：126-133,8.DOI:10.5732/cjc.011.10315
Reversing multidrug resistance by tyrosine kinase inhibitors
Reversing multidrug resistance by tyrosine kinase inhibitors
摘要
Abstract
Recently,a large number of tyrosine kinase inhibitors (TKIs) have been developed as anticancer agents.These TKIs can specifically and selectively inhibit tumor cell growth and metastasis by targeting various tyrosine kinases and thereby interfering with cellular signaling pathways.The therapeutic potential of TKIs has been hindered by multidrug resistance (MDR),which is commonly caused by overexpression of ATP-binding cassette (ABC) membrane transporters.Interestingly,some TKIs have also been found to reverse MDR by directly inhibiting the function of ABC transporters and enhancing the efficacy of conventional chemotherapeutic drugs.In this review,we discuss ABC transporter-mediated MDR to TKIs and MDR reversal by TKIs.关键词
Tyrosine kinase inhibitors/ multidrug resistance/ reversal effectsKey words
Tyrosine kinase inhibitors/ multidrug resistance/ reversal effects引用本文复制引用
Miao He,Min-Jie Wei..Reversing multidrug resistance by tyrosine kinase inhibitors[J].癌症（英文版）,2012,31(3):126-133,8.基金项目
This work was supported by grants from the National Natural Science Foundation of China (No. 30873097), Research Fund for the Doctoral Program of Higher Education of China (No.20092104110020), and Science and Technology Planning Project of Liaoning Province,China (No.2010225001). （No. 30873097）
