分析测试学报2012，Vol.31Issue(3)：261-266,6.DOI:10.3969/j.issn.1004-4957.2012.03.004
化妆品中24种过敏原的气相色谱-质谱法测定
Determination of 24 Allergens in Suspicious Cosmetics by Gas Chromatography - Mass Spectrometry
摘要
Abstract
A simultaneous determination method was developed for the reliable screening, quantification and confirmation of 24 allergens in cosmetics by gas chromatography - mass spectrometry ( GC - MS) . The 24 allergens were extracted from cosmetics with methanol, then determined by GC - MS with the external standard method under the selected ion mode ( SIM ) . The calibration curves showed good linearities in the range of 0. 2 - 100 mg/L with correlative coefficients (r ) larger than 0. 995. The detection limits were in the range of 2 - 10 mg/kg, and the average recoveries were 80% -104% with relative standard deviations of 1. 8% -9. 3% . The method was rapid, accurate and sensitive. The positive detection rate of 24 allergens in 150 samples of 77 patients using cosmetics was 78% , and there was at least one allergen measured value above 10 mg/kg in 81. 2% of the positive samples. 24 allergens in the cosmetics used by 71 patients were detected out and the detection rate was 92. 2% , which at least one allergen measured value above 10 mg/kg was 90. 1% . 24 allergens are the major allergens in cosmetic contact dermatitis.关键词
气相色谱-质谱/化妆品/过敏原/接触性皮炎Key words
gas chromatography - mass spectrometry/ cosmetics/ allergen/ contact dermatitis分类
化学化工引用本文复制引用
陈捷,焦红,叶弘毅,毕英杰,刘超,郑璇,战静,赖唯..化妆品中24种过敏原的气相色谱-质谱法测定[J].分析测试学报,2012,31(3):261-266,6.基金项目
国家质检总局科技计划项目(2009IK160) （2009IK160）
