广东医学2012，Vol.33Issue(7)：879-882,4.
辛伐他汀与环孢素A对大鼠经皮动脉血管成形术术后再狭窄作用的比较
Effects of CsA and simvastatin on the restenosis after percutaneous transluninal angioplasty of abdominal aorta in rats.
摘要
Abstract
Objective To ivestigate the difference between the effects of cyclosporin A (CsA) and simvastatin ( Sim) on the restenosis after percutaneous transluninal angioplasty of abdominal aorta in rats. Methods Fourty adult male SD rats were randomly divided into four groups: control group ( Group C) , balloon injury group ( Group BI) , ballon injury plus cyclosporin A group ( Group BI + CsA) , and ballon injury plus simvastatin group ( Group BI + Sim) . Since 3 days before surgery, CsA and Sim gavage were given to rats in Group BI + CsA and Group BI + Sim, respectively, while placebo treatment were given to Group C and Group BI until 28 days after surgery. Then specimens were obtained for evaluation of pathological change, aortic MCP - 1 mRNA expression and plasma MCP - 1 concentration, with HE staining, real -time PCR and ELISA, respectively. Results Significant hyperplasia of neointima, elevated plasma and aortic MCP -1 expression were revealed in Group BI, when comparing with those in Group C. Although the CsA and Sim treatment partially inhibited the balloon injury - induced neointima hyperplasia and MCP - 1 expression, they were elevated when comparing with those in controls. Conclusion CsA and Sim both partially inhibits the restenosis after the balloon injury via depression of inflammation, but there is no significant difference between the two drugs.关键词
球囊损伤/再狭窄/环孢素A/辛伐他汀/MCP-1Key words
balloon injury/restenosis/cyclosporin A/simvastatin/MCP - 1引用本文复制引用
张云飞,董颀,熊龙根..辛伐他汀与环孢素A对大鼠经皮动脉血管成形术术后再狭窄作用的比较[J].广东医学,2012,33(7):879-882,4.基金项目
广东省科技计划项目(编号:2010B031600140) （编号:2010B031600140）
