广东医学2012，Vol.33Issue(8)：1172-1174,3.
前列地尔对行急诊经皮冠状动脉介入术的急性心肌梗死患者氧化应激的影响
The effects of alprostadil on oxidative stress in acute myocardial infarction patient treated by emergency percutaneous coronary intervention
摘要
Abstract
Objective To investigate the effect of alprostadil on oxidative stress in acute myocardial infarction patients treated by emergency percutaneous coronary intervention ( PCI) . Methods Ninety - nine acute myocardial infarction patients with emergency PCI were randomly assigned into two groups. Control group (48 patients) were treated with conventional hydration therapy, while experimental group (51 patients) were given with 10 μg alprostadil in 20 mL sodium chloride solution before conventional therapy qd for 7 days. The SCr levels, SOD activity and MDA concentration at 24th hour, 48th hour, 72nd hour, and on 7th day were assessed. Results There was no significant difference in SCr level, SOD activity or MDA content between the two groups 24 hours after therapy ( P＞0. 05 ) . The SCr levels were significantly lower in experimental group 48 hours, 72 hours and 7 days after therapy than those in control group ( P＜0. 05 ) . Meanwhile , significant elevation of SOD activity and reduction in MDA content were revealed in experimental group 72 hours and 7 days after therapy, when comparing with those in control group ( P＜0. 05 ) . Conclusion Alprostadil can ease the oxidative stress in acute myocardial infarction patients treated by emergency PCI, and reduce the incidence of contrast - induced nephropathy.关键词
前列地尔/急性心肌梗死/氧化应激Key words
prostaglandin E1/acute myocardial infarction/oxidative stress引用本文复制引用
崔进,蒋作锋,黄伟光,徐元杰,劳丽霞,吴同果..前列地尔对行急诊经皮冠状动脉介入术的急性心肌梗死患者氧化应激的影响[J].广东医学,2012,33(8):1172-1174,3.基金项目
广东省医学科研基金资助项目(编号:A2011481),广州市医药卫生科技一般引导项目立项项目(编号:201102A213206) （编号:A2011481）
