中国妇幼健康研究2012，Vol.23Issue(2)：148-150,154,4.DOI:10.3969/j.issn.1673-5293.2012.02.006
围孕期暴露与后代先天性心脏病发生风险的关系
Relationship between exposure in progestational and pregnant period and risks of congenital heart disease among offsprings
摘要
Abstract
Objective To explore the relationship between pregnant women' s exposure in progestational and pregnant period and risks of congenital heart disease ( CHD ) among their offsprings. Methods A case control study was conducted. The case group consisted of 42 women with 28 gestational weeks or more and their offsprings were diagnosed with CHD in pregnant period or within 30 days after delivery. With multi-stage cluster sampling method 221 women delivering normal live births in the same period were randomly selected in Xi' an area as control group. Multiple logistic regression model was used to analyze the correlation between factors in progestational and pregnant period and the occurrence of CHD. Results In the studied factors in progestational and pregnant period, eugenics examination ( including premarital and pregnant examination ) was a protective factor for CHD [ OR value ( 95% CI) was 0. 90( 0. 24-0. 95 ), 0. 29( 0. 07-0. 32 ) and 0. 14( 0. 02-0. 32 ), respectively ]. The adverse environment exposed during pregnancy period, such as living in the area where emitting waste plant was around 1 000 meters, working in toxic exposure before pregnancy or during pregnancy, could increase the risk of CHD significantly [ OR value ( 95% CI) was 1. 36( 1. 01-1. 56 ) and 1. 98( 1.03-3. 57 ) respectively ]. Bad living habits such as using computer or watching TV for more than 1 hour per day, using microwave ovens usually, irregular sleep ( more than once a week ) and suffering from passive smoking during pregnancy were all risk factors for CHD [ OR value ( 95% CI) was 1. 77( 1.47-2. 65 ), 1. 34( 1.08-1. 43 ), 1. 09( 1. 02-1. 43 ) and 1. 36( 1. 11-1. 58 ), respectively ]. Mother having chronic diseases such as diabetes or hypertension during pregnancy was the highest risk for their offsprings suffering from CHD ( OR ( 95% CI) = 2. 80 ( 1. 62-4. 81 ), and getting fever or catching cold in early pregnancy were also risk factors[ OR value ( 95% CI) was 1. 67( 1. 36-4. 93 ) and 1. 59( 1. 44-5. 84 ), respectively ]. No significant conclusion was drawn between taking drugs such as cold drugs, oral contraceptives and anti-inflammatory drugs during pregnancy and the risk of CHD. Conclusion Eugenics examination has significant protective effect on the occurrence of CHD, while adverse environment, bad life style and diseases in pregnancy are all risk factors of CHD.关键词
先天性心脏病/病例对照/保护因素/危险因素Key words
congenital heart disease ( CHD )/case control study/protective factors/risk factors分类
医药卫生引用本文复制引用
杨柳,杨文方,王翔,刘黎明,张春利..围孕期暴露与后代先天性心脏病发生风险的关系[J].中国妇幼健康研究,2012,23(2):148-150,154,4.基金项目
陕西省科学技术研究发展计划资助项目(No.2005K14-G7) （No.2005K14-G7）
