中国妇幼健康研究2012，Vol.23Issue(2)：172-175,4.DOI:10.3969/j.issn.1673-5293.2012.02.013
早期自然流产患者蜕膜组织中ICAM-1/Mac-1的表达
Expression of ICAM-1 and Mac-1 in decidual tissues of patients with early spontaneous abortion
摘要
Abstract
Objective To explore the relationship between intracellular adhesion molecule-l( ICAM-1 )/macrophage differentiation antigen-l( Mac-1 ) and early spontaneous abortion ( SA ) by detecting the expression of ICAM-1 and Mac-1 in decidual tissues of patients with early SA. Methods The expression of ICAM-1 and Mac-1 in the deciduous tissues of 35 women with early SA and of 30 with normal abortion was detected by S-P immunohistochemistry. The relationship between ICAM-l/Mac-1 and SA was analyzed with confocal scanning laser microscope ( CLSM ). Results The expressive intensity of ICAM-1 and Mac-1 was significantly stronger in the decidual stromal cells in SA group than that in control group ( Z = -3.056, P = 0. 002; Z = -2. 132, P = 0.033 ), but the protein expressive intensity of ICAM-1 and Mac-1 in decidual glandular epithelial cells in SA group was slightly lower than that in control group ( Z = - 1. 978, P = 0. 048; Z = - 1. 973 , P =0. 048 ). The ICAM-1 and Mac-1 expression in the deciduous tissues overlapped under CLSM in both groups. Conclusion The high expression of ICAM-1 and Mac-1 in decidual stromal cells and low expression in decidual glandular epithelial cells may correlate with the occurrence of early SA.关键词
早期自然流产/细胞间黏附因子-1/巨噬细胞分化抗原-1/免疫组织化学/激光扫描共聚焦显微镜/蜕膜Key words
early spontaneous abortion ( SA )/ intracellular adhesion molecule -1 ( ICAM-1 )/macrophage differentiation antigen-l( Mac-1 )/ immunohistochemistry/ laser scanning confocal microscope ( CLSM )/ decidua分类
医药卫生引用本文复制引用
王立芹,于学文,张永爱,周小兰,褚静,李静..早期自然流产患者蜕膜组织中ICAM-1/Mac-1的表达[J].中国妇幼健康研究,2012,23(2):172-175,4.基金项目
陕西省自然科学基础研究计划资助项目(2009JM4016) （2009JM4016）
陕西省教育厅科研计划资助项目(11jk0713) （11jk0713）
