国际口腔医学杂志2012，Vol.39Issue(3)：360-364,5.DOI:10.3969/j.issn.1673-5749.2012.03.022
胰岛素样生长因子-Ⅰ及其与髁突软骨发育的调控
Insulin -like growth factor -Ⅰand its regulation on the development of mandibular condylar cartilage
摘要
Abstract
The postnatal condylar cartilage lives in complex mechanical micro-circumstances, and its growth and modification depends on proliferation and differentiation of condylar chondrocytes. Insulin-like growth factor (IGF) - I is one of the important growth factors during growth and development in the condylar cartilage. At the cellular level, IGF- Ⅰ exerts its biological actions through the binding and activation of IGF- Ⅰ , and its bioefficacy is modulated by IGF binding proteins (IGFBP). IGF- Ⅰ induces variety cellular responses, including cell proliferation, differentiation, and aopotosis, promoting matrix synthesis and taking part in intercellular signal mechanotransduc- tion. The article reviews IGF- Ⅰ and its receptor, IGFBP and its role and mechanism on the development of postnatal mandibular condylar cartilage.关键词
胰岛素样生长因子/髁突软骨/发育/作用机制Key words
insulin-like growth factor/ condylar cartilage/ development/ role and mechanism分类
生物科学引用本文复制引用
江莉婷..胰岛素样生长因子-Ⅰ及其与髁突软骨发育的调控[J].国际口腔医学杂志,2012,39(3):360-364,5.基金项目
上海市科委医学引导基金资助项目(114119a3500) （114119a3500）
