广西医学2012，Vol.34Issue(4)：388-389,399,3.
NK及B细胞水平对肝癌家族聚集性影响的研究
The Study of the Impact of Natural Killer Cells and B Cells on the Familial Aggregation of Hepatocellular Carcinoma
摘要
Abstract
Objective To investigate the effect of natural killer cells( NK cells ) and B cells on the familial aggregation of hepatocellular carcinoma. Methods Ninety four familial members( observation group ) with hepatocellular carcinoma in regions of high hepatocellular carcinoma incidence rate in Guangxi and 94 healthy controls( control group ) matched with the same nationality,gender,about ±5 years of age,and residential area were selected. The levels of NK cells and B cells in the peripheral blood from the subjects were tested by flow cytometry. Results The level of NK cells in observation group was ( 15.03 ±7.05 )% ,while in control group was ( 15.03 ±7.05 )% ;the level of B cells in observation group was (6.27 ±2.72)% ,while in control group was (5.90 ±2.52)% ,there was no significant difference between the two groups in the level of NK and B cells( P >0.05 ). The ratio of NK/B cells in observation group was 2.76 ± 1.69,while in control group was 3.46 ±2.84, there was significant difference between the two groups( P <0.05 ). Conclusion The significant reduction of the ratio between NK cells and B cells in the body might cause dysfunction of immune system, promote tumor development and induce familial aggregation of hepatocellular carcinoma.关键词
原发性肝癌/NK细胞/B细胞/家族聚集性Key words
Natural Killer Cell/ B cell/ Hepatocellular carcinoma/ Familial aggregation分类
医药卫生引用本文复制引用
陈务卿,贺荣,吴继周,吴健林,臧宁,李国坚,邓一鸣,韦颖华,胡蝶飞,宁秋悦..NK及B细胞水平对肝癌家族聚集性影响的研究[J].广西医学,2012,34(4):388-389,399,3.基金项目
国家自然科学基金(30960170) （30960170）
广西医药卫生科研课题(桂卫重2008049) （桂卫重2008049）
