河北医学2012，Vol.18Issue(4)：432-435,4.DOI:10.3969/j.issn.1006-6233.2012.04.003
EGFR单核苷酸多态性和食管癌放射敏感性的相关性研究
Research on the Association between Single Nucleotide Polymorphism of the Epidermal Growth Factor Receptor and Sensitivity of Radiotherapy for Esophageal Cancer
李长春 1李光明 1胡欣 1付曦 1潘荣强 1郭翠华 1文世明1
作者信息
摘要
Abstract
Objective: To investigate the association between single nucleotide polymorphism ( SNP ) rs763317 in genetic variations of the epidermal growth factor receptor ( EGFR ) and the clinical sensitivity in patients with esophageal cancer treated with radiotherapy. Method: A total of 160 esophageal cancer patients treated with radiotherapy were analyzed. Polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) and MassARRAY SNP methods were conducted to analyzed the genotypes. Results: The effective rate of radiotherapy 160 patients was 50% . Rs763317 was associated with the efficacy of radiotherapy . The response rate for the rs763317 AA was significantly higher than that for the GA or GG ( 65. 5% vs 9. 1% , P<0. 001 ). Conclusion: rs763317 polymorphism is associated with the clinical efficacy of radiotherapy and may be a potential biomarker to predict the clinical outcome in esophageal cancer patients treated with radiotherapy. There's no correlatron between GA, GG and sensitivity of radiotherapy in patients with esophageal cancer.关键词
EGFR/SNP/食管癌/放射治疗/敏感性Key words
Epidermal growth factor receptor/Single nucleotide polymorphism/Esophageal cancer/Radiotherapy/Sensitivity引用本文复制引用
李长春,李光明,胡欣,付曦,潘荣强,郭翠华,文世明..EGFR单核苷酸多态性和食管癌放射敏感性的相关性研究[J].河北医学,2012,18(4):432-435,4.
