摘要
Abstract
Objective: To study the effect and adverse effect of implanting sustained-release 5- fluorou-racil during hepatolobectomy to oppose metastasis of liver cancer . Method: 63 patients diagnosed with liver cancer were divided into two groups: group Ⅰ ( n = 32 ), ordinary chemotherapy group, patients with conventional chemotherapy after operation; group Ⅱ( n = 31 ), patients with sustained-release 5-fluorouracil during operation. Two groups were visited 1 year, observed the adverse effect, recurrence rate and death rate. Result: There's significant difference in liver function before operation( P>0. 05 ) of two groups. ALT, AST, TBL,PT,AFP in group Ⅱ were much lower than group Ⅰ after operation( P<0. 05 );The recurrence and transferring rate of group Ⅱ was much lower than group Ⅰ ( P<0. 05 ); The incidence and mortality of group Ⅱ were much lower than group Ⅰ ( P<0. 05 ). Conclusion: The treatment of sustained-release 5- fluorouracil during hepatolobectomy can effectively reduce the rate of transferring, recurrence and death of liver cancer patients, increase the patients' compliance and tolerance, it may be a new therapy for patients with liver cancer after hepatectomy.关键词
5-氟尿嘧啶缓释剂/肝癌/残肝断面植入/部分肝叶切除术Key words
Sustained-release 5- fluorouracil/Liver cancer/Intrahepatic embedding/Hepatectomy
