华南农业大学学报2012，Vol.33Issue(2)：235-238,4.
氟苯尼考颗粒与氟苯尼考粉在猪体内的药物动力学比较
Comparative Pharmacokinetics of Florfenicol Granule and Florfenicol Powder in Pigs
摘要
Abstract
Fourteen healthy pigs were divided into two groups of 7 pigs each. The pigs in group A were o-rally administrated with single dose of florfenicol powder at 30 mg/kg. The pigs in group B were also orally administrated with single dose of florfenicol granule at 30 nig/kg. Comparative study on the pharmaco-kinetics of florfenicol powder and florfenicol granule was carried out. Plasma concentration of florfenicol was determined by HPLC. The concentration-time data of florfenicol were analyzed by non-compartmental model based on pharmacokinetic software WinNonlin 5.2. 1. The main pharmacokinetic parameters of powder following oral administration were :f,/2p = (10. 22±0.18) h, k, = ( 0. 07 ± 0. 01) h -1, tmax= (1.67 ±0.48) h, Cmax = (24.68 ±1.13) μg · mL-1, AUC = (190.97 ±16.60) μg · mL-1 · H, MRT = (8. 33 ±0. 42) h, tcp = (17. 66 ± 1. 52) h. The main pharmacokinetic parameters of granule following oral administration were :t1/2β= (16. 36 ±4. 14) h,ke = (0. 05 ±0. 01) h-', tmax = (5.71 ± 0.47) h, Cmax = (12.23 ±0.78) μg · mL-1, AUC = (155.44 ±6. 59) mg · mL-1 · H, MRT = (14. 96 ± 0. 35) h, tcp = ( 23. 03 ± 0. 49) h. The results showed the granule of florfenicol after oral administration had slower elimination and longer effective time of the blood medicine density maintenance.关键词
氟苯尼考/颗粒/粉剂/猪/药物动力学Key words
florfenicol/ granule/ powder/ pigs/ pharmacokinetics分类
农业科技引用本文复制引用
刘帅帅,杨刚,赵永达,方秋华,黄显会..氟苯尼考颗粒与氟苯尼考粉在猪体内的药物动力学比较[J].华南农业大学学报,2012,33(2):235-238,4.基金项目
“十一五”国家科技支撑计划“兽用抗菌药物新制剂的研制与应用”(2006BAD31B06). （2006BAD31B06）
