基础医学与临床2012，Vol.32Issue(4)：437-441,5.
FGF10及其受体FGFR2Ⅲb在小鼠肾脏发育中的表达
Expression of FGF10 and FGFR2Ⅲb in development of mouse kindey
摘要
Abstract
Objective To observe the expression and location of FGF10 and FGFR2 Ⅲb during kidney development of mouse in order to investigate their roles in kidney development. Methods Immunohistochemistry technique and Western blotting method were used to examine the expression of FGF10 and FGFR2 Ⅲb at embryonic day 12., 14、16、18 and neonatal day 1、7、14、21,42 in the developing mouse kidney. Results FGF10 and FGFR2 Ⅲb, were weakly expressed in the ureteric buds at E12d and then with the renal development, FGF10 and FGFR2 Ⅲb were expressed mainly in distal tubules and collecting ducts. FGF10 was expressed also in the proximal convoluted tubule. FGFR2 Ⅲb was not expressed in the proximal tubule. The renal corpuscles in each development stage was not positive for expression of FGF10 and FGFR2 Ⅲb. Western blot showed that during kidney development, the expressions of FGF10 and FGFR2 Ⅲb were increased firstly and then decreased. Conclusions FGF10 and FGFR2 Ⅲb probably play an important role in the renal development.关键词
FGF10/FGFR2Ⅲb/肾发育/小鼠Key words
FGF10/ FGFR2Ⅲb/ kidney development/ mouse分类
医药卫生引用本文复制引用
李佳,田娟,郭敏..FGF10及其受体FGFR2Ⅲb在小鼠肾脏发育中的表达[J].基础医学与临床,2012,32(4):437-441,5.基金项目
辽宁省教育厅科研项目(L2010274) （L2010274）
