基础医学与临床2012,Vol.32Issue(4):453-456,4.
IL-23/IL-17轴在银屑病免疫发病机制中的作用
The IL-23/IL-17 axis in the immunopathogenesis of psoriasis
摘要
Abstract
Psoriasis is a chronic inflammatory skin disease characterized by abnormal activated T cells infiltration. Recently ,Thl7 cells and IL-23/ IL-17 axis has being recognized as a key player and potential therapeutic target in psoriasis. IL-23 is able to induce Thl7 cell activation with production of pro-inflammatory cytokines such as IL-17 A, IL-17F, IL-22. Thl7-related cytokines play a functional role in psoriasis and other autoimmune diseases.关键词
IL-23/Th17/IL-17/银屑病Key words
IL-23 /Thl7/ IL-17/ psoriasis分类
医药卫生引用本文复制引用
赵京霞,王燕,底婷婷,刘欣,李萍..IL-23/IL-17轴在银屑病免疫发病机制中的作用[J].基础医学与临床,2012,32(4):453-456,4.基金项目
国家自然科学基金(81072810) (81072810)
北京市科技计划重大课题(D08050703550901) (D08050703550901)