江苏大学学报（医学版）2012，Vol.22Issue(2)：101-103,109,4.
玻璃苣醇提物对慢性抑郁模型小鼠脑组织中神经递质的影响
Effects of the ethanol extractive of Borago officinalis on neurotransmitter in the brain tissue of mouse model of chronic depression
摘要
Abstract
Objective; The effects of the extractive of Borago officinalis on norepinephrine (NE) ,dopa-mine and 5-hydroxytryptamine(5-HT)in mouse model of depression with chronic stress were investigated after establishing of chronic stress mouse models of depression ; and to discuss its prevention and cure effects and their possible mechanisms. Methods; Established chronic stress mouse models of depression by using singly housed and long-trem unpredictable mild stress ( CUMS) ; and to determine the change of brain mono-amine neurotransmitters of chronic stress depression model mice by using enzyme -linked immunosorbent assay (ELISA). Results; The monoamine neurotransmitters (5-HT,NE, dopamine) contents in model mice were significantly less than normal group. The high, medium group of ethanol extractive from Borago offici-nalis all could increase the contents of 5-HT,NE,dopamine of mice with chronic stress depression ;and the low group of ethanol extractive from Borago officinalis approached a raising trend ,but no statistical significance. Conclusion; The Borago officinalis can elevate the contents of the 5-HT,NE and dopamine in the brian which were the possible mechanisms of the prevention and cure effect of the Borago officinalis .关键词
玻璃苣/抑郁症/脑内单胺递质Key words
Borago officinalis/depressed syndrome/brain monoamine neurotransmitters分类
医药卫生引用本文复制引用
刚宏林,何志一,刘相辉,马跃..玻璃苣醇提物对慢性抑郁模型小鼠脑组织中神经递质的影响[J].江苏大学学报（医学版）,2012,22(2):101-103,109,4.基金项目
黑龙江省青年科学基金资助项目(QC2009) （QC2009）
