昆明医学院学报2012，Vol.33Issue(2)：55-59,5.
2型糖尿病患者下肢动脉粥样硬化与骨密度改变的研究
The Correlation between Lower Extrimity Atherosclerosis and Bone Mineral Density in Type 2 Diabetes Mellitus Patients
摘要
Abstract
Objective To explore the correlation between lower extremity atherosclerosis (LEA) and bone mineral density in type 2 diabetes mellitus (T2-DM) patients. Methods Two hundred and nineteen T2-DM were enrolled in this study. Severity of LEA was examined by Doppler Ultrasound of Aloka -a 10 (Japan). According to severity of LEA score, the subjects were divided into the control (re=65) , mild (n=62) , moderate (n=56) and severe (n=36) groups. The bone mineral density (BMD) in lumbar vertebrate and femoral bone was measured by Dual- energy X- ray absorptiometry (DEXA) made in America. The clinical factors and biochemical parameters of patients in different groups were observed and the correlation between lower extremity atherosclerosis and bone mineral density. Results (1) With the increase in the severity of LEA, the HBAlc, FBG, 2HPBG, TC, TG and LDL were gradually increased , but HDL was decreased in the four groups, there was significant differences (P<0.05). (2) The severity score of LEA was negative correlated with the BMD in lumbar vertebrat and femoral bone. (3) Multivariate Logistic regression analysis showed the change of BMD, HBAlc and TC were major risk factors of LEA T2- DM .Conclusions With the increase in the severity of LEA in T2- DM, the decrease of BMD is more obvious. The decrease of BMD is a risk factor of LEA production and development.关键词
2型糖尿病/下肢动脉/动脉粥样硬化Key words
Type 2 diabetes mellitus/ Artery of lower extremity/ Atherosclerosis分类
医药卫生引用本文复制引用
王玲,卜锐,宋滇平,王丹,杨秋萍..2型糖尿病患者下肢动脉粥样硬化与骨密度改变的研究[J].昆明医学院学报,2012,33(2):55-59,5.基金项目
云南省自然科学基金资助项目(2009CD166) （2009CD166）
