兰州大学学报（医学版）2012，Vol.38Issue(1)：29-34,6.
甘草酸的选择性水解及其与唾液酸形成分子复合物的初步研究
Study of selective hydrolysis of glycyrrhizin and the molecular complex of glycyrrhizin and sialic acid
摘要
Abstract
Objective To investigate the selective hydrolysis of glycyrrhizn and its pharmacoiogic mechanism. Methods β-glucuronidase was extracted from poultry to catalyze the hydrolysis of glycyrrhizin, differential thermal analysis and spectrum method were applied to investigate the characteristics of the complex of glycyrrhizin and sialic acid. Results Glycyrrhizin could be efficiently hydrolyzed to mono-β-glucuronide glycyrrhizin acid and at the same time the molecule complex of glycyrrhizin and sialic acid could be formed in the solution. Conclusion It is feasible to product mono-β-glucuronide glycyrrhizin with β-glucuronidase extracted from poultry and the formation of molecular complex provides basis for further study on pharmacoiogic mechanism of glycyrrhizin.关键词
甘草酸/β-葡萄糖醛酸苷酶/唾液酸/分子复合物Key words
glycyrrhizin/β-glucurouidase/sialic acid/molecular complex分类
医药卫生引用本文复制引用
陈桂玲,赵全义,段瑞哲..甘草酸的选择性水解及其与唾液酸形成分子复合物的初步研究[J].兰州大学学报（医学版）,2012,38(1):29-34,6.基金项目
甘肃省自然科学基金(3ZS061-A25-091) （3ZS061-A25-091）
兰州大学交叉学科青年创新基金(LZU200527) （LZU200527）
