兰州大学学报（医学版）2012，Vol.38Issue(1)：53-56,4.
丙泊酚对肠缺血再灌注大鼠肿瘤坏死因子-α的影响
Effect of propofol on tumor necrosis factor after intestinal ischemia-reperfusion in rats
华玉芳 1石翊飒 1任冬青2
作者信息
- 1. 兰州大学第二医院麻醉科,甘肃兰州730030
- 2. 甘肃省人民医院麻醉科,甘肃兰州730000
- 折叠
摘要
Abstract
Objective To study the potential role and possible protective effect of propofol on tumor necrosis factor-a (TNF-α) release after intestinal ischemia-reperfusion. Methods' Twenty four rats were randomly divided into three groups: sham-operated control group (S, n=8), ischemia-reperfusion+NS group (I/R+NS, n=8) and ischemia-reperfusion+propofol group (I/R+P, n=8). Ischemic reperfusion models were made by occluding the superior mesenteric artery for 1 minute, followed by 120 minutes reperfusion. S and I/R+NS group were pretreated with sodium chloride 10 mL/(kg-h) before operation, while I/R+P were pretreated with propofol 10 mg/(kg.h) before occlusion. The expression levels of TNF-a in the small intestinal tissue and plasma were evaluated by enzyme-linked immunosorbent assay (ELISA) and the condition of mucous membrane lesion was observed under optional microscope in each group. Results Propofol could availably alleviate the pathologic lesion of small intestine mucosa caused by intestinal ischemia-reperfusion and could decrease the elevation of plasma and small intestinal tissueTNF-α levels after intestinal ischemia-reperfusion. Conclusion Propofol can reduce the injury of ischemia-reperfusion in rat. Such protective effect may be achieved through the inhibition of TNF-α release.关键词
丙泊酚/小肠/缺血再灌注/肿瘤坏死因子-αKey words
propofol/small intestine/ischemia reperfusion/tumor necrosis factor-α分类
医药卫生引用本文复制引用
华玉芳,石翊飒,任冬青..丙泊酚对肠缺血再灌注大鼠肿瘤坏死因子-α的影响[J].兰州大学学报（医学版）,2012,38(1):53-56,4.
