兰州大学学报（医学版）2012，Vol.38Issue(1)：61-64,4.
高剂量率近距离腔内超分割放射治疗宫颈癌的临床研究
Clinical study of high dose rate brachytherapy on cervical carcinoma
摘要
Abstract
Objective To explore the possibility and biological effect in clinic by applying unconventional fractionation of intracavitary brachytherapy. Methods In vitro radiotherapy + high dose rate brachytherapy (HDR) cavity radiotherapy were applied in the treatment: the accelerator 6 MV-X lines by Simens were used in vitro illumination; around entire pelvic cavity 2 wilds central technology illuminations etc were also used; integral dose was 46-50 Gy, 23-25 fractions, for 5 weeks. When external irradiation entire pelvic cavity dosage was 30 Gy, 15 fractions the pelvic cavity central kept off the lead (4 cm×10 cm) and started to work in short-distance cavity treatment. The 192Ir high dose rate breech loading therapeutic equipment was used, without cavity internal radiation in vitro illumination at the same day. In the HDR cavity the ultra divisiongroup: point A (Ⅱb, Ⅲ) received 4 Gy perfraction, twice daily of intracavitary irradiation at point A. The intrafraction interval was more than 6 hours daily. The total dose at point A was 40 Gy in 10 fractions, 5 days, 3-4 weeks. In HDR cavity conventional division group: point A (ⅡI b, Ⅲ) received 6 Gy perfraction. The total dose at point A was 36 Gy in 6 fractions, 6 days, 6 weeks. Results By the end of radiotherapy, local control of 24 patients complete remission + partial remission was 100% and the control was 95.83% after a year. Early vagina reaction was: I degree for 10 cases, Ⅱ degree for 11 cases and Ⅲ degree for 3 cases. The reaction did not cause any break-up of treatment. Conclusion Enough fractionation including fraction number and dose perfraction are very important to improve the treatment effect and decrease the later complications of the HDR intracavitary brachytherapy for cervix carcinoma. The method is applicable because of its satisfactory early effects. Further follow-up is needed to evaluate its survival rate as well as later tissue injury.关键词
宫颈癌/后装治疗/高剂量率/超分割放疗Key words
cervical carcinoma/brachytherapy/high dose rate brachytherapy/hyperfractionted radiontherapy分类
医药卫生引用本文复制引用
任锦霞,王小虎,赵林,高力英,吉宏,刘志强,罗莉,杜瑞琴..高剂量率近距离腔内超分割放射治疗宫颈癌的临床研究[J].兰州大学学报（医学版）,2012,38(1):61-64,4.基金项目
甘肃省科技厅科技支撑计划项目(090NKCA091) （090NKCA091）
