临床骨科杂志2012，Vol.15Issue(2)：199-201,3.
不同颈椎内固定融合术式实验兔模型的建立
Rabbit model for different internal fixation and fusion methods of cervical spine
摘要
Abstract
Objective To establish animal model of different operation methods for internal fixation and fusion of cervical spine. Methods Sixty New Zealand white rabbits were randomly divided into three model groups. The first model group ( A group ) were undergone anterior cervical spine internal fixation and fusion. The second model group ( B group ) were undergone posterior cervical spine internal fixation and fusion. The third model group ( C group ) were undergone anterior and posterior cervical spine internal fixation and fusion at the same time. After operation, the rabbits were examined respectively by X-ray at first, third month and then ten rabbits in every group were sacrificed for pathological observation. Results By the time, three model groups had abnormal X-ray signs in the segment of internal fixation and fusion: In A,C groups, the intervertebral space disappeared. In B,C groups, the vertebral plate and spinous process space were disappeared. By the end of first month, trabeculae of bone and collagen fiber were in order and regulation. The periosteum side had some fibrous tissue. These may manifestation there had ossification phenomenon. After three months, the ossification was similar to body of vertebra or vertebral plate. The refraction of collagen fibers was powerfully and arrange an order direction. Conclusions The models for internal fixation and fusion of cervical spine were simple, easy and reliability. It can provide a satisfactory model to study and research healing of spinal column disease.关键词
颈椎/脊柱融合术/内固定/疾病模型,动物Key words
cervical vertebrae/ spinal fusion/ internal fixation/ disease models, animal分类
医药卫生引用本文复制引用
夏良政,徐宏光,刘平,陈学武..不同颈椎内固定融合术式实验兔模型的建立[J].临床骨科杂志,2012,15(2):199-201,3.基金项目
皖南医学院中青年教师科研基金项目(编号:WK200606BF) （编号:WK200606BF）
