临床神经病学杂志2012，Vol.25Issue(1)：3-7,5.
聚集素基因多态性与Alzheimer病相关性的Meta分析
Meta-analysis of association between clusterin gene polymorphism and Alzheimer disease
杜文津 1陈晋文 1陈大伟 1李华军1
作者信息
- 1. 100142 北京,解放军空军总医院东楼神经科
- 折叠
摘要
Abstract
Objective To explore the association between clusterin(CLU) gene rslll36000 polymorphism and Alzheimer disease (AD). Methods Databases such as PubMed, EMBASE, AlzGene, CBM and CHKD were searched for relevant case-control studies of association between clusterin gene polymorphism and Alzheimer disease based on the defined selection criteria. The included studies were tested for control population in Hardy-Weinberg equilibrium and heterogeneity between populations. Odds ratios (OR) and 95% confidence interval ( CI) of CLU rsl1136000 genotype ( TT + TC ) /CC and allele T/C distribution were analyzed with Review Manager Version 5.0 and Stata 11. 0 software using the fixed effects model. Publication bias was tested by bias analysis. Results Ten literatures with twenty-nine different population groups were studied. The subgroups were Caucasian, Asian, African descent, Hispanic and others based on ethnics. There was no significant heterogeneity among subgroups. The summary OR for studies in Caucasian with frequency of (TT + TC)/CC genotype and T/C allele at rsl 1136000 locus in CLU gene were 0. 83 (95%C/:0.79-0. 86, Z = 8.44) and 0. 88 (95% CI-.Q. 85 -0. 90, Z = 9.74), which showed significant difference ( all P < 0.001). Those in Asian, African descent, Hispanic and other ethnic group showed no significant difference. There was no publication bias existing. Conclusions In Caucasian, CLU gene rsl 1136000 polymorphism may contribute to susceptibility of AD and the T allele may reduce the risk of AD. But no definite associations were found in Asian, African descent, Hispanic and other ethnic group.关键词
聚集素/Alzheimer病/基因多态性/Meta分析Key words
clusterin/ Alzheimer disease/ polymorphism/ Meta-analysis分类
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杜文津,陈晋文,陈大伟,李华军..聚集素基因多态性与Alzheimer病相关性的Meta分析[J].临床神经病学杂志,2012,25(1):3-7,5.
