临床神经外科杂志2012，Vol.9Issue(1)：15-17,3.DOI:10.3969/j.issn.1672-7770.2012.01.006
立体定向植入125Ⅰ粒子治疗复发脑恶性胶质瘤
Interstitial irradiation with stereotactically implanted 125Ⅰ seeds for the treatment of recurrent gliomas
吕学明 1吕福林 1袁绍纪 1李际文 1孙希炎 1张荣伟 1卢培刚 1朱伟杰 1刘子生 1陈援朝1
作者信息
- 1. 250031 济南军区总医院神经外科全军神经外科专科中心
- 折叠
摘要
Abstract
Objective To study the role of 125I seed interstitial irradiation with stereotactically implantation in the treatment of the recurrent gliomas. Methods Croup A: 40 cases as histological diagnosis after surgical resection, and recurrence of malignant glioma (patients to take a voluntary basis) , within the l25 I into glioma with stereotactically, tumor interstitial radiotherapy, In conjunction with radiotherapy linear accelerator. Croup B 20 patients with glioma after radiotherapy using linear particle accelerator as a control group. Observation of objective response, clinical benefit response, toxicity, complications and survival. Results The survival rates of 6 and 12 months time of two groups was 57.0% vs 32.6% and 20.5% vs 12.5% (P < 0.05). The median survival time of two groups was 8.0 months to 4.0 months(P <0.05 ). The average survival time of two groups was 8.5 months to 5.5 months(P <0.05). Conclusions 125I seed interstitial irradiation with stereotactically implantation is effective and can prolong survival and improve quality of life, with no obvious toxicity. It is a simple, safe and effective method in the treatment of recurrent gliomas.关键词
脑胶质瘤/放射治疗/间质内放疗/立体定向Key words
glioma/ radiotherapy/ interstitial irradiation/ stereotactic detection分类
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吕学明,吕福林,袁绍纪,李际文,孙希炎,张荣伟,卢培刚,朱伟杰,刘子生,陈援朝..立体定向植入125Ⅰ粒子治疗复发脑恶性胶质瘤[J].临床神经外科杂志,2012,9(1):15-17,3.
