临床与实验病理学杂志2012，Vol.28Issue(5)：502-505,4.
非特指外周T细胞淋巴瘤中PTEN的改变
Genetic aberration of PTEN in peripheral T cell lymphoma, not otherwise specified
摘要
Abstract
Purpose To investigate the genetic changes of tumor suppressor gene PTEN in PTCL-NOS, and to explore its relationship with the development of PTCL-NOS and other clinicopathological parameters. Methods Thirty-six cases of PTCL-NOS were studied by fluorescence in-situ hybridization ( FISH ) using interphase dual-colour probes. The probes were generated from BAC clones RP11 - 380G5 corresponding to PTEN gene. Correlation of the genetic changes with patients prognosis and other clinical parameters was analyzed. Results Loss of heterozygosity ( LOH ) of PTEN presented in 8/36 cases; Kaplan-Meier survival analysis indicated there was a trend that the group with PTEN gene change had a poorer prognosis than the group without PTEN gene change ( P < 0. 05 ), but there was no correlation of the gene alteration with tumor stage, site, age, sex and LDH level ( P >0. 05 ). Conclusion A significant percentage of PTCL-NOS carry the genetic alteration of PTEN that may play an important role in the pathogenesis of PTCL-NOS and the e-valuation of the patient' s prognosis.关键词
外周T细胞淋巴瘤/肿瘤抑制基因/PTEN基因/荧光原位杂交Key words
peripheral T-cell lymphoma/ tumor suppressor genes/ PTEN gene/ FISH分类
医药卫生引用本文复制引用
朱文娟,张建中..非特指外周T细胞淋巴瘤中PTEN的改变[J].临床与实验病理学杂志,2012,28(5):502-505,4.基金项目
国家自然科学基金(30771215) （30771215）
