临床与实验病理学杂志2012，Vol.28Issue(5)：514-517,4.
涎腺腺样囊性癌中ADAM-17的表达及临床意义
The clinicopathological significance of ADAM-17 expression in salivary adenoid cystic carcinoma
章建国 1张弘 2李峰 2黄华 1施公胜1
作者信息
- 1. 南通大学附属医院病理科,南通,226001
- 2. 南通大学附属医院消化实验室,南通,226001
- 折叠
摘要
Abstract
Purpose To investigate the expression of ADAM-17 in salivary adenoid cystic carcinoma and to explore its correlation with clinical behavior and pathological characters. Methods 48 cases of the paraffin-embedded tissues and 20 cases of fresh tissues of SACC were collected to detect the ADAM-17 protein by immunohistochemistry and mRNA expression levels by RT-PCR. We also analyzed the correlation between the expression of ADAM-17 and the clinical pathological parameters. Results The expression of ADAM-17 protein was 72. 9%( 35/48 ) in the 48 cases, and the average relative expression level of ADAM-17 mRNA levels was 0. 40 ±0. 18 in the 20 cases, which were higher than that in the normal control group ( P <0. 001 ). And both were relation with the tumor size, TNM stage and the patient survival time. Conclusion ADAM17 is overexpressed in SACC and possibly mediate the cancer growth, invasion and metastasis, which is expected to become a new therapeutic target.关键词
涎腺肿瘤/腺样囊性癌/免疫组化/ADAM-17/RT-PCRKey words
salivary gland neoplasms/ adenoid cystic carcinoma/immunohistochemistry/ ADAM-17/ RT-PCR分类
医药卫生引用本文复制引用
章建国,张弘,李峰,黄华,施公胜..涎腺腺样囊性癌中ADAM-17的表达及临床意义[J].临床与实验病理学杂志,2012,28(5):514-517,4.
