临床与实验病理学杂志2012，Vol.28Issue(5)：526-529,4.
潮州地区高危型人乳头瘤病毒载量与宫颈病变的关系
The relationship between the HR-HPV load and cervical lesions in Chaozhou area
摘要
Abstract
Purpose To study the relationship between the HR-HPV load and cervix lesions. Methods The real-time PCR was used to detect the HR-HPV DNA of Chaozhou rural women age from 35 to 60, the CT value was received during the test. For 2 731 HR-HPV DNA positive cases, HybriMax was used to genotype, and LCT was used to diagnosis. For LSIL or even worse cases, a diagnostic colposcope and biopsy were performed. According to the diagnosis of LCT and histopathology test, total cases were divide into NILM, ASCUS, LSIL, HSIL and SCC group. Then, each group was further divided into 4 subgroups ( HPV52, HPV16, HPV58 and multiple HR-HPV infections ) according to the HR-HPV subtype. The CT value of each group was statistically analyzed with variance analysis by SPSS version 16. 0 software. Results The CT value was decreased with the cervix lesions getting worse, the lower CT value was typically observed in the higher rank cervix lesions group, and there was significant difference between each group( P <0. 05 ). However, the significant difference was only found in NILM group ( between HPV58 and multiple HR-HPV infections group ) and ASCUS group ( between HPV16 and multiple HR-HPV infections group ), it was not observed between other groups. Conclusions There was a positive relationship between the HR-HPV load and cervix lesions, the HR-HPV load was one of the risk factor of cervix lesions.关键词
宫颈病变/人乳头瘤病毒/病毒载量/液基薄层细胞学Key words
cervix lesions/human papillomavirus/ viral load/ thinprep liquid-based cytologic test分类
医药卫生引用本文复制引用
罗招云,杨立业,林敏,陈强..潮州地区高危型人乳头瘤病毒载量与宫颈病变的关系[J].临床与实验病理学杂志,2012,28(5):526-529,4.基金项目
广东省医学科研基金 (A2011760,B2008179) （A2011760,B2008179）
