中国临床保健杂志2012，Vol.15Issue(1)：36-39,4.DOI:10.3969/J.issn.1672-6790.2012.01.014
老年男性代谢综合征患者血睾酮水平与骨密度及骨转换指标的相关性研究
The correlation between serum testosterone and bone mineral density and bone turnover markers in aged male patients with metabolic syndrome
摘要
Abstract
Objective To investigate the relationship between serum testosterone (T) levels and parameters of bone mineral density (BMD)and bone turnover markers in aging male patients with metabolic syndrome (MS). Methods One hundred and eleven aged 60-90 years male patients were divided into two groups, namely MS group (sixty-one) and non-MS group (fifty). Serum T, N-MID-Osteocalcin (N-MID-OC) , total type I collagen N-terminal extension peptide (PINP) ,serum β-collagen special series ( β-CTX)levels were measured,and left forearm,left hip and lumbar vertebrae BMD were delected by dual energy X-ray densitometer. The relationship between T levels and parameters of BMD and bone turnover markers was analysed. Results T, N-MID-OC, PINP, left forearm BMD, left hip BMD,lumbar vertebrae BMD levels were lower andp-CTX level were higher in MS group than those in non-MS group (P<0.05). As the increase of MS contents,serum T,N-MID-OC,PINP levels and lumbar vertebrae BMD,hip BMD,forearm BMD decreased gradually,and β-CTX level increased. In MS group,there were significant positive correlation respectively between the levels of T and N-MID-OC,PINP,lumbar vertebrae BMD,hip BMD,forearm BMD. There was a negative relationship between the levels of serum T and p-CTX. Conclusion Serum T level is closely related to BMD and biochemical markers of bone turnover in aged male patients with metabolic syndrome. Lower serum T level may be an the independent factor for osteoporosis in aged men.关键词
代谢综合征/骨密度/睾酮/骨质疏松/男人/老年人Key words
Metabolic syndrome/ Bone density/ Testosterone/ Osteoporosis/ Men/ Aged分类
医药卫生引用本文复制引用
姚慧,康冬梅,赵翠平,郑茂,刘燕,朱翔..老年男性代谢综合征患者血睾酮水平与骨密度及骨转换指标的相关性研究[J].中国临床保健杂志,2012,15(1):36-39,4.基金项目
安徽省科技计划项目(08020303073) （08020303073）
