农药学学报2012，Vol.14Issue(1)：1-16,16.DOI:10.3969/j.issn.1008-7303.2012.01.01
植物病原真菌对甾醇生物合成抑制剂类(SBIs)杀菌剂的抗药性研究进展
Research advances on the resistance of plant pathogenic fungi to SBIs fungicides
摘要
Abstract
The sterol biosynthesis inhibitors (SBIs) killed pathogenic fungi by inhibiting differentenzymes activity in biosynthesis pathway of sterols to interfere or block sterol biosynthesis. The recent research progresses of resistance of plant pathogenic fungi to SB Is were summarized, including the resistance status, genetic mechanism, physiological and biochemical mechanism, molecular mechanism and management strategy. According to the results of laboratory studies and field experiments, the resistance of pathogenic fungi against SBIs might cause by one or more than one mechanisms. ABC, MFS transport protein gene and CYP51 protein gene were regarded as the important molecular mechanisms. Among them, ABC transport protein gene was considered as a non-special vehicle to excrete fungicides from inner to outer of cell membrane by flippase enzyme. The over- and background-expression of MFS transport protein gene played key role in the resistance of pathogenic fungi. While point-mutation and over-expression of CYP51 protein gene was easily occurred in plant pathogenic fungi, which decreased the binding affinity of protein to fungicides and thereby resulted in the resistance against SBIs. With the rapid development of molecular biology technology and incorporating with other disciplines, the design of multiple action sites of sterol biosynthesis inhibitors based on the information of resistant related genes, proteins and regulation pathway would be possible, which would then extend the service life of SBIs.关键词
植物病原真菌/甾醇生物合成抑制剂/抗药性机制/研究进展Key words
plant pathogenic fungi/sterol biosynthesis inhibitors (SBIs)/resistant mechanism/research advances分类
农业科技引用本文复制引用
叶滔,马志强,毕秋艳,牛芳胜,韩秀英,张小风,王文桥,张利辉..植物病原真菌对甾醇生物合成抑制剂类(SBIs)杀菌剂的抗药性研究进展[J].农药学学报,2012,14(1):1-16,16.基金项目
国家公益性行业(农业)科研专项项目(nyhyzx201203035). （农业）
