青岛大学学报（自然科学版）2012，Vol.25Issue(1)：47-50,4.DOI:10.3969/j.issn.1006-1037.2012.02.011
海带多糖对铅中毒大鼠生殖系统的影响
Effects of Alginate on Reproductive System of Wistar Rats with Lead Poisoning
王园园 1付占海 2毛晓红 1石振艳 1岳旺1
作者信息
- 1. 青岛大学,医学院,山东青岛266021
- 2. 青岛大学,青岛市人口和计划生育科学技术研究所,山东青岛266071
- 折叠
摘要
Abstract
To study the effect of alginate on the reproductive system of the lead poisoning Wistar rats, the following methods was taken; 1) normal control group, After 1 week's exposure to lead, the Wistar rats were randomly divided into 5 groups; 2) model group(0. 3%Pb(AC)2); 3) Penicillamine group(90mg · Kg-1) 4)high-dose alginate group(200 mg · Kg-1); 5) middle-dose alginate group( 100 mg · Kg-1); 6) low-dose alginate group(50mg · Kg-1). After 1 month treatment, blood lead, genital weight, sperm activity, sperm deformity rate and endocrine function impact were measured. Results show that alginate can lower the blood lead in Wistar rats, improve the epididymis and testis index(P<0. 05), lower sperm deformity and mortality(P<0. 05) , and improve T, FSH levels(P<0. 05). The alginate has a protective effect on the reproductive system in Wistar rats with lead poisoning, and is expected to develop into a natural and low toxicity protection medicine to treat lead poisoning.关键词
大鼠/铅中毒/生殖系统/海带多糖Key words
Wistar rats/lead poisoning/reproductive system/alginate分类
医药卫生引用本文复制引用
王园园,付占海,毛晓红,石振艳,岳旺..海带多糖对铅中毒大鼠生殖系统的影响[J].青岛大学学报（自然科学版）,2012,25(1):47-50,4.
