中国海洋大学学报（自然科学版）2012，Vol.42Issue(3)：21-26,6.
酚类污染物对菲律宾蛤仔抗氧化和解毒系统相关酶活性的影响
Effects of Phenolic Compounds on Enzyme Activities of Antioxidant and Detoxification Systems in Ruditapes philippinarum
摘要
Abstract
Phenolic compounds including nonylphenol, octylphenol, 2,4-dichlorophenol and bisphenol A are widely concerned due to their endocrine disrupting activity and carcinogenicity. Taking Ruditapes philippinarum as an experimental species, this paper studies the activities of antioxidant and detoxification enzymes including superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) in gill and visceral tissues in response to the exposure of these four phenolic chemicals. The results showed that the activities of SOD, CAT and GST did not change significantly under exposure to low concentrations of nonylphenol (0. 05~0. 2 mg/L). The enzyme activities were, however, significantly inhibited under a high dose (0. 4 mg/L) with an inhibition rate of 56. 6%, 59. 0% and 35. 5% respectively. Within the experimental concentration range (0. 05~0. 4 mg/L), dichlorophenol inhibited the visceral CAT activity significantly and bisphenol A inhibited the gill GST activity significantly. The three enzymes showed a dose response change in response to phenolic exposure, therefore, they could be adopted as bio-markers indicating phenolic pollution in aquatic environment.关键词
酚类污染物/超氧化物歧化酶/过氧化氢酶/谷胱甘肽硫转移酶/生物标志物Key words
phenolic compounds/superoxide dismutase/catalase/glutathion S-transf erase/biomarker分类
资源环境引用本文复制引用
张海丽,边海燕,杨跃志,李正炎..酚类污染物对菲律宾蛤仔抗氧化和解毒系统相关酶活性的影响[J].中国海洋大学学报（自然科学版）,2012,42(3):21-26,6.基金项目
国家水体污染控制与治理科技重大专项(2009ZX07528-006-03) （2009ZX07528-006-03）
海洋公益性行业科研专项(201005012-2)资助 （201005012-2）
