山东医药2012，Vol.52Issue(1)：25-27,3.
食管癌三维适形和调强放疗剂量学对比研究
Comparison of dose distributions between conformal and intensity modulated radiotherapy for the esophageal carcinoma
摘要
Abstract
Objective To evaluate the dose distribution between three dimensional conformal radiotherapy(3D-CRT) and intensity modulated radiotherapy( IMRT) in tumor target area and organs at risks. Methods Twenty patients with thoracic esophageal carcinoma underwent CT simulation. The IMRT plan and 3D-CRT plan were designed for each patient. The prescription dose in 95% of PTV volume was 60 Gy. PTV and organs at risk in 3-DCRT and IMRT plans were compared. Results Dose parameters of PTV50 of IMRT plan was superior than those of 3DCRT( P <0.01). The volume parameters V100 of PTV50 of IMRT plan was higher than those of 3DCRT plan. Dose and volume parameters of PTV60 were similar between the 3DCRT plan and IMRT plan. The mean dose of PTV60 of IMRT plan was lower than that of 3DCRT plan(P <0. 01) . The conformity indexes of PTV50 and PTV60 in the IMRT plan were higher than those in 3DCRT plan. The V5 , V10, V15 , V20 of the total lung in the IMRT plan were all lower than those in the 3D-CRT plan( P < 0. 01). The maximum dose of spinal cord of IMRT plan was higher than that of 3D-CRT plan; the mean heart dose was similar. But the doses of spinal cord and heart were limited in tolerant range. Conclusion Considering the target conformal degree and target dose,IMRT is superior to 3D-CRT. Additionally, it can reduce the exposure dose of the lung.关键词
食管肿瘤/三维适形放疗/适形调强放疗/剂量学/治疗计划系统Key words
esophageal neoplasms/3D-conformal radiotherapy/intensity modulated radiotherapy/radiation dosime-try/treatment planning system分类
医药卫生引用本文复制引用
刘智华,胡海芹,罗辉,徐建华,钟军..食管癌三维适形和调强放疗剂量学对比研究[J].山东医药,2012,52(1):25-27,3.基金项目
江西省卫生厅科技计划项目(20061141). （20061141）
