山东医药2012，Vol.52Issue(7)：32-34,3.
Notch1与Jagged1蛋白在大肠腺癌组织中的表达及临床病理意义
Expression of Notch1 and Jagged1 protein in colorectal adenocarcinoma tissue
李王丽 1陈学军1
作者信息
- 1. 辽宁医学院病理学教研室,辽宁锦州121001
- 折叠
摘要
Abstract
Objective To investigate the roles of Notchl and Jaggedl protein in the occurrence and development of colorectal adenocarcinoma(CA). Methods Immunohistochemical PV-9000 method and Western blot were used to detect the expression of Notchl protein and Jaggedl protein in 78 cases of CA( CA group ) , 40 cases of colorectal adenoma( adenoma group) and 40 cases of normal c lorectal tissue (5 cm far from the CA, normal group) , and their relationship with the clinic pathological parameters were analyzed. Results The positive expression rate of Notchl and Jaggedl protein in CA group were significantly higher than those in adenoma group and normal group (P < 0. 05 ) ;the expression intensity of Notchl and Jaggedl protein were closely associated with histological grading, Dukes stage and lymph nodemetastasis of CA ( P < 0. 05 ) . There was positive correlation between the expression of Notchl and Jaggedl protein in CA group ( r = 0. 407, P <0.05). Conclusion Notchl and Jaggedl protein play important roles in the pathway of carcinogenesis and progression of CA.关键词
Notch1/Jagged1/免疫组织化学/Western blottingKey words
Notchl/ Jaggedl/ immunohistochemistry/ Western blotting分类
医药卫生引用本文复制引用
李王丽,陈学军..Notch1与Jagged1蛋白在大肠腺癌组织中的表达及临床病理意义[J].山东医药,2012,52(7):32-34,3.
