山东医药2012，Vol.52Issue(8)：57-59,3.
低密度脂蛋白胆固醇异常在2型糖尿病家系中的家族聚集性及相关因素分析
Familial clustering and related factors of abnormal serum low density lipoprotein cholesterol in families with type 2 diabetes
霍丽丽 1纪立农 2邓丽丽1
作者信息
- 1. 北京积水潭医院,北京100035
- 2. 北京大学人民医院
- 折叠
摘要
Abstract
Objective To explore whether serum low density lipoprotein cholesterol (LDL-C) is a heritable trait in families with type 2 diabetes mellitus ( DM) and analyze its related factors. Methods Two hundred and ninety five nuclear families with two or more type 2 DM patients were used in the study. There were totally 978 family members. The probands were divided into two groups: 131 normal LDL-C probands ( < 2.6 mmol/L) and 163 high LDL-C probands( ≥2. 6 mmol/L). Serum LDL-C were compared between two groups. Multiple regression analysis was used to examine the related factor. Results First-degree relatives of type 2 DM in high LDL-C group had significantly higher levels of TCHO and LDL-C, even after FPG and HbA1c adjusted. In multiple regression analysis, LDL-C of first-degree relatives of type 2 DM was associated with LDL-C of the probands, HbA1c and age. First-degree relatives of non DM in high LDL-C group had significantly higher levels of TCHO and LDL-C. In multiple regression analysis, LDL-C of first-degree relatives of non DM was associated with LDL-C of the probands, HbA1c and age. Conclusions There is a familial aggregation of abnormal LDL-C in this collection of type 2 DM families. LDL-C could be associated with HbA1c and age.关键词
低密度脂蛋白胆固醇/糖尿病,2型/一级亲属Key words
low density lipoprotein cholesterol/ diabetes mellitus, type 2/ first-degree relatives分类
医药卫生引用本文复制引用
霍丽丽,纪立农,邓丽丽..低密度脂蛋白胆固醇异常在2型糖尿病家系中的家族聚集性及相关因素分析[J].山东医药,2012,52(8):57-59,3.
