同济大学学报（医学版）2012，Vol.33Issue(1)：48-52,5.DOI:10.3969/j.issn1008-0392.2012.01.010
胃食管反流病患者食管黏膜Ki-67及Caspase-3的表达
Expression of Ki-67 and Caspase-3 in esophageal mucosa of patient with gastroesophageal reflux disease
程静 1陈莹 1王琛 1许树长1
作者信息
- 1. 同济大学附属同济医院消化内科,上海200065
- 折叠
摘要
Abstract
Objective To investigate the expression and significance of Ki-67 and Caspase-3 in the esophageal mucosa of patients with gastroesophageal reflux disease (GERD). Methods Sixty GERD patients, including 20 cases of reflux esophagitis (RE), 20 cases of non-erosive reflux disease (NERD) and 20 cases of Barrett esophagus (BE) were enrolled in the study; esophageal mucosa samples were also taken from 15 normal healthy subjects as controls. The esophageal samples were examined with routine histopathology; the expressions of Ki-67 and Caspase-3 proteins in the esophageal mucosa were detected by immunohistochemistry and Western-blot methods. Results Prominent proliferation in esophageal mucous membrane was observed histopathologically in all 3 groups of GERD patients. The positive rates of Ki-67 and intensity of expression in NERD, RE and BE groups were 80% , 85% and 95% , which were significantly higher than that of controls (6. 7% , P <0.05); while the expression of Caspase-3 in NERD, RE, and BE groups were 95% , 90% and 75% , only BE group were lower than control group (100.0%, P <0. 05). Conclusion Expression of Ki-67 and Caspase-3 may be associated with the proliferation of esophageal mucous membrane and the change of tissue resistance in gastroesophageal reflux disease.关键词
Ki-67/Caspase-3/胃食管反流病Key words
Ki-67/ Caspase-3/ GRED分类
医药卫生引用本文复制引用
程静,陈莹,王琛,许树长..胃食管反流病患者食管黏膜Ki-67及Caspase-3的表达[J].同济大学学报（医学版）,2012,33(1):48-52,5.
