同济大学学报（医学版）2012，Vol.33Issue(1)：53-58,6.DOI:10.3969/j.issn1008-0392.2012.01.011
肺结核合并慢性阻塞性肺疾病患者免疫功能的变化及意义
Immune function changes in patients with lung tuberculosis complicated by chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the changes of immune function in patients with lung tuberculosis complicated by chronic obstructive pulmonary disease (COPD). Methods One hundred and eighteen patients of lung tuberculosis complicated with COPD (study group) and 120 patients with lung tuberculosis(TB control group) admitted to hospital in January 2008 to January 2011 were enrolled in the study; 110 healthy subjects served as normal controls. The NK cells and T lymphocyte subsets in peripheral whole blood samples were detected by flow cytometry. The levels of IgM, IgG, and IgA were measured by immunoturbidimetry. The levels of sIL-2R, TNF-a, IL-6 and JPN--y were measured with sandwich ABC-ELISA method. Results The percentages of NK cells, CD4 and CD4/CD8 ratio in study group and in TB control group were lower than those in normal control group(P <0.01). The levels of CD8 in study group were higher than those in normal control group(P < 0.001). The levels of CD4 and CD4/CD8 ratio in study group were lower than those in TB control group(P <0. 001). The levels of IgM, IgG and IgA in study group were lower than those in normal control group (P < 0.05). There were no significant differences between study group and TB control group in the levels of IgG and IgA (P > 0. 05). There were no significant differences between TB control group and normal control group in levels of IgG and IgM(p >0.05). The levels of sIL-2R, TNF-a, IL-6 and IFN-7 in study group and in the TB control group were higher than those in healthy subjects (P < 0. 05). The levels of sIL-2R and IFN-7 in study group were higher than those in TB control group (P < 0, 05). There were no significant differences between study group and TB control grou in level of TNF-a and EL-6. Conclusion The results reveal that both cellular immunity and humoral immunity are impaired in patients with lung tuberculosis complicated by COPD, the impairment is more severe than that in patients with simple lung tuberculosis.关键词
肺结核/慢性阻塞性肺疾病/天然杀伤细胞/T淋巴细胞/免疫球蛋白/细胞因子Key words
pulmonary tuberculosis/ pulmonary disease/ chronic obstructive/ killer cells/ natural/ T lymphocytes/ immunoglobulins/ cytokines分类
医药卫生引用本文复制引用
沈芸,唐神结,孙华,郝晓晖..肺结核合并慢性阻塞性肺疾病患者免疫功能的变化及意义[J].同济大学学报（医学版）,2012,33(1):53-58,6.基金项目
国家十一五重大专项课题"特大城市结核病综合防治模式研究"(2009ZX10003-017) （2009ZX10003-017）
